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Plos Genetics : Risk Alleles for Systemic Lupus Erythematosus in a...

By: Mark I. McCarthy

Description : Systemic lupus erythematosus (SLE) is a genetically complex disease with heterogeneous clinical manifestations. Recent studies have greatly expanded the number of established SLE risk alleles, but the distribution of multiple risk alleles in cases versus controls and their relationship to subphenotypes have not been studied. We studied 22 SLE susceptibility polymorphisms with previous genome-wide evidence of association (p,561028) in 1919 SLE cases from 9 i...

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Plos Genetics : Genetic Diversity in Cytokines Associated with Imm...

By: Bret A. Payseur

Description : Pathogens are believed to drive genetic diversity at host loci involved in immunity to infectious disease. To date, studies exploring the genetic basis of pathogen resistance in the wild have focussed almost exclusively on genes of the Major Histocompatibility Complex (MHC): the role of genetic variation elsewhere in the genome as a basis for variation in pathogen resistance has rarely been explored in natural populations. Cytokines are signalling molecules...

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Plos Genetics : a Missense Mutation in Ppard Causes a Major Qtl Ef...

By: Jonathan Flint

Description : Chinese Erhualian is the most prolific pig breed in the world. The breed exhibits exceptionally large and floppy ears. To identify genes underlying this typical feature, we previously performed a genome scan in a large scale White Duroc 6 Erhualian cross and mapped a major QTL for ear size to a 2-cM region on chromosome 7. We herein performed an identicalby- descent analysis that defined the QTL within a 750-kb region. Historically, the large-ear feature ha...

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Plos Genetics : Small Rna-directed Epigenetic Natural Variation in...

By: Joseph R. Ecker

Description : Progress in epigenetics has revealed mechanisms that can heritably regulate gene function independent of genetic alterations. Nevertheless, little is known about the role of epigenetics in evolution. This is due in part to scant data on epigenetic variation among natural populations. In plants, small interfering RNA (siRNA) is involved in both the initiation and maintenance of gene silencing by directing DNA methylation and/or histone methylation. Here, we ...

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Plos Genetics : Retrotransposon Activates Ectopic Ptf1 Expression ...

By: Wayne N. Frankel
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