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Bulletin of the World Health Organization : 1983; Volume 61, Number 4, Year 1983 61 (4), Pages 597-609: Allaitement Maternel et Regulation de la Fecondite ; Connaissances Actuelles et Incidences sur l’Orientation des Programs

By World Health Organization

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Book Id: WPLBN0000000237
Format Type: PDF eBook
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Reproduction Date: 2005

Title: Bulletin of the World Health Organization : 1983; Volume 61, Number 4, Year 1983 61 (4), Pages 597-609: Allaitement Maternel et Regulation de la Fecondite ; Connaissances Actuelles et Incidences sur l’Orientation des Programs  
Author: World Health Organization
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
Publication Date:
Publisher: World Health Organization

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Organization, W. H. (n.d.). Bulletin of the World Health Organization : 1983; Volume 61, Number 4, Year 1983 61 (4), Pages 597-609. Retrieved from http://members.worldlibrary.net/


Description
Medical Reference Publication

Excerpt
For quite some time it has been apparent to BCG IT-orkers that there are considerable variations in the tuberculin allerg and local ~accination lesions resulting from different batches of BCG vaccine. Even when comparable groups of children are vaccinated and later tuberculin-tested with uniform procedures, the effects are appreciably dift'erent from batch to batch. Variations must occur in the vaccine itself:. and two simple sources of variation can be readily conceil-ed. First, the total number of organisms in the vaccine can hardly be constant. In preparing vaccine, the mass of bacilli gro~x-no n the culture medium is pressed to semi-dryness ; then a k e d \$-eight of this mass is suspended in diluent. As the weighed mass still contains some moisture, however, the actual weight of bacilli, and consequently the actual number of organisms per unit volume of vaccine, can vary considerably. Secondly, though vaccine is prepared with presumably living organisms, some may be killed during its preparation-for example, in the grinding process-and some may die from other causes before it is used. Thus, most vaccines may be regarded as having at least two relatively simple sources of variation : the number of organisms per ml, and the relative proportion of Living and dead bacilli.

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