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Bulletin of the World Health Organization : 1983; Volume 61, Number 4, Year 1983 61 (4), Pages 653-659: The El Tor Cholera Epidemic in Dhaka in 1974 and 1975

By World Health Organization

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Book Id: WPLBN0000000240
Format Type: PDF eBook
File Size: 0.3 MB
Reproduction Date: 2005

Title: Bulletin of the World Health Organization : 1983; Volume 61, Number 4, Year 1983 61 (4), Pages 653-659: The El Tor Cholera Epidemic in Dhaka in 1974 and 1975  
Author: World Health Organization
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
Publication Date:
Publisher: World Health Organization

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Organization, W. H. (n.d.). Bulletin of the World Health Organization : 1983; Volume 61, Number 4, Year 1983 61 (4), Pages 653-659. Retrieved from http://members.worldlibrary.net/


Description
Medical Reference Publication

Excerpt
Racial differences in drug response A pharmacokinetic study, recently published in the New England Journal of Medicine, has confirmed an impression widely held among clinicians that patients of oriental descent are more responsive to the actions of propranolol than those of Western origin. Whereas reduction of heart rate differed by a factor of 2 to 3 in Americans of Chinese and European descent, the mean reduction of arterial blood pressure differed, more unexpectedly, by a factor of ten. Completely unanticipated, however; was the finding that the metabolicclearance of the drug was substantially faster, rather than slower, among the oriental subjects. The true difference in pharmacodynamic susceptibility is thus even greaterthan is clinically evident.

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