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Toxicological Review of Acrolein

By Environmental Protection Agency

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Book Id: WPLBN0000020702
Format Type: PDF eBook
File Size: 0.3 MB
Reproduction Date: 2007
Full Text

Title: Toxicological Review of Acrolein  
Author: Environmental Protection Agency
Volume:
Language: English
Subject: Ecology, Natural resource issues, Environemtal protection
Collections: Environmental Awareness Library Collection
Historic
Publication Date:
Publisher: United States Environmental Protection Agency

Citation

APA MLA Chicago

Agency, E. P. (n.d.). Toxicological Review of Acrolein. Retrieved from http://members.worldlibrary.net/


Description
Excerpt: This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. Note: This document may undergo revisions in the future. The most up-to-date version will be made available electronically via the IRIS Home Page at http://www.epa.gov/iris.

Table of Contents
CONTENTS – TOXICOLOGICAL REVIEW OF ACROLEIN (CAS No. 107-02-8) FOREWORD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v AUTHORS, CONTRIBUTORS, AND REVIEWERS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vi 1. INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. CHEMICAL AND PHYSICAL INFORMATION RELEVANT TO ASSESSMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 3. TOXICOKINETICS RELEVANT TO ASSESSMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3.1. ABSORPTION AND DISTRIBUTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3.2. METABOLISM AND EXCRETION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3.3. PHYSIOLOGICALLY-BASED TOXICOKINETIC MODELS . . . . . . . . . . . . . . . 7 4. HAZARD IDENTIFICATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 4.1. STUDIES IN HUMANS--EPIDEMIOLOGY, CASE REPORTS, CLINICAL CONTROLS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 4.1.1. Acute Exposures (<24 hours) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 4.1.2. Exposures (> 24 Hours . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 4.2. ACUTE STUDIES IN ANIMALS—ORAL AND INHALATION . . . . . . . . . . . . 11 4.2.1. Lethality Studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 4.2.2. Sensory Irritation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 4.2.3. Other Effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4.3. PRECHRONIC AND CHRONIC STUDIES AND CANCER BIOASSAYS IN ANIMALS--ORAL AND INHALATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 4.3.1. Noncancer Toxicity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 4.3.1.1. Inhalation Studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 4.3.1.2. Oral Administration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 4.3.1.3. Dermal Administration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 4.3.2. Cancer Assessment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 4.3.2.1. Inhalation Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 4.3.2.2. Oral Administration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 4.3.2.3. Injection Studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 4.3.2.4. Initiation and Promotion Studies . . . . . . . . . . . . . . . . . . . . . . . . 34 4.4. REPRODUCTIVE/DEVELOPMENTAL STUDIES-ORAL AND INHALATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 4.5. OTHER STUDIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38 4.5.1. In Vitro Toxicity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38 4.5.2. Intraperitoneal/Intragastric/Intravenous Toxicity . . . . . . . . . . . . . . . . . . . 41 4.5.3. Genotoxicity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 4.5.3.1. DNA Adduct Formation, Sister Chromatid Exchange and DNA-Protein Cross-links . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42

 

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