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Toxicological Review of Naphthalene

By Environmental Protection Agency

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Book Id: WPLBN0000021500
Format Type: PDF eBook
File Size: 1.1 MB
Reproduction Date: 2007
Full Text

Title: Toxicological Review of Naphthalene  
Author: Environmental Protection Agency
Volume:
Language: English
Subject: Ecology, Natural resource issues, Environemtal protection
Collections: Environmental Awareness Library Collection
Historic
Publication Date:
Publisher: United States Environmental Protection Agency

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Agency, E. P. (n.d.). Toxicological Review of Naphthalene. Retrieved from http://members.worldlibrary.net/


Description
Excerpt: FOREWORD: The purpose of this Toxicological Review is to provide scientific support and rationale for the hazard and dose-response assessment in IRIS pertaining to chronic exposure to naphthalene. It is not intended to be a comprehensive treatise on the chemical or toxicological nature of naphthalene. In Section 6, EPA has characterized its overall confidence in the quantitative and qualitative aspects of hazard and dose response. Matters considered in this characterization include knowledge gaps, uncertainties, quality of data, and scientific controversies. This characterization is presented in an effort to make apparent the limitations of the assessment and to aid and guide the risk assessor in the ensuing steps of the risk assessment process. For other general information about this assessment or other questions relating to IRIS, the reader is referred to EPA’s Risk Information Hotline at 202-566-1676.

Table of Contents
CONTENTS—TOXICOLOGICAL REVIEW FOR NAPHTHALENE (CAS No. 91-20-3) FOREWORD .................................................................v AUTHORS, CONTRIBUTORS, AND REVIEWERS................................ vi LIST OF ABBREVIATIONS .................................................. viii 1. INTRODUCTION...........................................................1 2. CHEMICAL AND PHYSICAL INFORMATION RELEVANT TO ASSESSMENTS ..... 2 3. TOXICOKINETICS RELEVANT TO ASSESSMENTS ............................2 3.1. ABSORPTION....................................................2 3.2. DISTRIBUTION ..................................................3 3.3. METABOLISM ...................................................3 3.4. ELIMINATION AND EXCRETION ..................................6 4. HAZARD IDENTIFICATION .................................................7 4.1. STUDIES IN HUMANS—EPIDEMIOLOGY, CASE REPORTS, CLINICAL CONTROLS .....................................................7 4.1.1. Hemolytic Anemia ...........................................7 4.1.2. Lethality ...................................................8 4.1.3. Cataracts ...................................................9 4.1.4. Cancer .....................................................9 4.2. PRECHRONIC AND CHRONIC STUDIES AND CANCER BIOASSAYS IN ANIMALS—ORAL AND INHALATION .............................10 4.2.1. Oral Exposure ..............................................10 4.2.2. Inhalation Exposure .........................................14 4.2.3. Other Routes of Exposure ....................................16 4.3. REPRODUCTIVE/DEVELOPMENTAL STUDIES .....................18 4.4. OTHER ........................................................20 4.4.1. Cancer/Noncancer Studies Related to Lung .......................20 4.4.2. Studies With Methylnaphthalene ...............................21 4.4.3. Other Cancer Studies ........................................24 4.4.4. Genotoxicity Studies.........................................24 4.5. SYNTHESIS AND EVALUATION OF MAJOR NONCANCER EFFECTS AND MODE OF ACTION -- ORAL AND INHALATION .....................25 4.5.1. Inhalation .................................................25 4.5.2. Oral ......................................................29 4.6. WEIGHT-OF-EVIDENCE EVALUATION AND CANCER CHARACTERIZATION ...........................................33 4.7. SUSCEPTIBLE POPULATIONS ....................................34

 

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