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Toxicological Review of Quinoline

By Environmental Protection Agency

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Book Id: WPLBN0000021501
Format Type: PDF eBook
File Size: 0.2 MB
Reproduction Date: 2007
Full Text

Title: Toxicological Review of Quinoline  
Author: Environmental Protection Agency
Volume:
Language: English
Subject: Ecology, Natural resource issues, Environemtal protection
Collections: Environmental Awareness Library Collection
Historic
Publication Date:
Publisher: United States Environmental Protection Agency

Citation

APA MLA Chicago

Agency, E. P. (n.d.). Toxicological Review of Quinoline. Retrieved from http://members.worldlibrary.net/


Description
Excerpt: This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. This document may undergo revisions in the future. The most up-to-date version will be available electronically via the IRIS Home Page at http://www.epa.gov/iris.

Table of Contents
CONTENTS—TOXICOLOGICAL REVIEW FOR QUINOLINE (CAS No. 91-22-5) FOREWORD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v AUTHORS, CONTRIBUTORS, AND REVIEWERS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vi 1. INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. CHEMICAL AND PHYSICAL INFORMATION RELEVANT TO ASSESSMENTS . . . . . 2 3. TOXICOKINETICS RELEVANT TO ASSESSMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 3.1. ABSORPTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 3.2. METABOLISM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 3.3. DISTRIBUTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3.4. EXCRETION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 4. HAZARD IDENTIFICATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 4.1. STUDIES IN HUMANS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 4.2. PRECHRONIC AND CHRONIC STUDIES AND CANCER BIOASSAYS IN ANIMALS—ORAL AND INHALATION . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 4.3. REPRODUCTIVE/DEVELOPMENTAL STUDIES IN ANIMALS— ORAL AND INHALATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 4.4. OTHER STUDIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 4.4.1. Other In Vivo Studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 4.4.2. Genotoxicity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 4.5. SYNTHESIS AND EVALUATION OF MAJOR NONCANCER EFFECTS . . 13 4.6. WEIGHT-OF-EVIDENCE EVALUATION AND CANCER CHARACTERIZATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 4.6.1. Human . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 4.6.2. Animal . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 4.6.3. Mode of Action . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4.7. SUSCEPTIBLE POPULATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4.7.1. Possible Childhood Susceptibility . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4.7.2. Possible Gender Differences . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 5. DOSE-RESPONSE ASSESSMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 5.1. ORAL REFERENCE DOSE (RfD) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 5.2. INHALATION REFERENCE CONCENTRATION (RfC) . . . . . . . . . . . . . . . . . . 19 5.3. CANCER ASSESSMENT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 5.3.1. Choice of Study/Data with Rationale and Justification . . . . . . . . . . . . . 19 5.3.2. Dose-Response Data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19

 

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