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Toxicological Review of Barium and Compounds

By Choudhury, Harlal D.

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Book Id: WPLBN0000068689
Format Type: PDF eBook
File Size: 0.4 MB
Reproduction Date: 2007
Full Text

Title: Toxicological Review of Barium and Compounds  
Author: Choudhury, Harlal D.
Volume:
Language: English
Subject: Ecology, Natural resource issues, Environemtal protection
Collections: Environmental Awareness Library Collection
Historic
Publication Date:
Publisher: United States Environmental Protection Agency

Description
Excerpt: This document and summary information on IRIS have received peer review both by EPA scientists and by independent scientists external to EPA. Subsequent to external review and incorporation of comments, this assessment has undergone an Agencywide review process whereby the IRIS Program Manager has achieved a consensus approval among the Office of Research and Development; Office of Air and Radiation; Office of Prevention, Pesticides, and Toxic Substances; Office of Solid Waste and Emergency Response; Office of Water; Office of Policy, Planning, and Evaluation; and the Regional Offices.

Table of Contents
CONTENTS FOREWORD .................................................................v AUTHORS, CONTRIBUTORS, AND REVIEWERS ................................ vi 1. INTRODUCTION...........................................................1 2. CHEMICAL AND PHYSICAL INFORMATION RELEVANT TO ASSESSMENTS .....3 3. TOXICOKINETICS RELEVANT TO ASSESSMENTS ............................5 3.1. ABSORPTION....................................................5 3.1.1. Gastrointestinal Absorption ....................................5 3.1.2. Respiratory Tract Absorption...................................6 3.1.3. Dermal Absorption...........................................7 3.2. DISTRIBUTION ..................................................7 3.3. ELIMINATION AND EXCRETION ..................................7 4. HAZARD IDENTIFICATION .................................................7 4.1. STUDIES IN HUMANS—EPIDEMIOLOGY, CASE REPORTS, AND CLINICAL CONTROLS ............................................8 4.1.1. Oral Exposure ..............................................8 4.1.2. Inhalation Exposure .........................................10 4.2. PRECHRONIC/CHRONIC STUDIES AND CANCER BIOASSAYS IN ANIMALS—ORAL AND INHALATION .......................13 4.2.1. Oral Exposure .............................................13 4.2.1.1. Animal Studies With Adequate Diets .....................13 4.2.1.2. Animal Studies With Restricted Diet .....................21 4.2.2. Inhalation Exposure .........................................23 4.3. REPRODUCTIVE/DEVELOPMENTAL STUDIES—ORAL AND INHALATION ...................................................23 4.3.1. Oral Exposure .............................................23 4.3.2. Inhalation Exposure ........................................24 4.4. OTHER STUDIES................................................25 4.4.1. Acute Toxicity Data.........................................25 4.4.2. Mechanistic Studies—Cardiovascular Toxicity ....................26 4.4.3. Intratracheal Administration ..................................27 4.4.4. Carcinogenicity Studies—Topical Administration .................27 4.4.5. Genotoxicity...............................................28 4.5. SYNTHESIS AND EVALUATION OF MAJOR NONCANCER EFFECTS AND MODE OF ACTION—ORAL AND INHALATION .....................28

 

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