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Environmental Health Perspectives December 1973 : Comments on and Summary of Panel On-Assessment of in Vitro and in Vivo Mutagenicity Data with Regard to Safety Evaluation

By Abramamson, S.

Government Reference Publication

Excerpt: It seems obvious that the 45 years of cussed chromosome aberrations in man, Dr. experience in assessing the genetic hazards Lewis treated methods for assessing somatic from ionizing radiation can serve as a model hazards, and Dr. Ramel touched on the need approach for assessing the vast world of for adequate training of qualified personnel environmental mutagens. I am extremely in carrying out mutagen testing and the proimpressed with the three-tier approach sug- blems associated in this area. gested by Bridges and also strongly feel that We opened up the discussion to all the it would be most useful to establish a roent- participants after each speaker had comgen equivalent mutagen dose estimate as pleted his presentaticn to permit considerable described by both Crow and Bridges. This at exchange of views. least will permit assessing the mutagen in This was a truly stimulating discussion. terms of genetic risk to man. I should like to Many different viewpoints were expressed, point out the fact that in the past year both and I believe everyone had an opportunity the United Nations Scientific Committee to make his views known. on the Effects of Atomic Radiation Finally I should like to quote from the (UNSCEAR) and the Biological Effects of genetics section of the BEIR committee re- Ionizing Radiation (BEIR) committee of the port on recommendations for estimating National Academy of Sciences have com- genetic risks, which I think are particularly pleted in depth and up-dated reports on gen- relevant based on the present discussions: etic risk estimates for man.


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