World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : Virulence Attributes and Hyphal Growth of C. Neoformans Are Quantitative Traits and the Mata Allele Enhances Filamentation, Volume 2

By MacKay, Trudy

Click here to view

Book Id: WPLBN0003923480
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : Virulence Attributes and Hyphal Growth of C. Neoformans Are Quantitative Traits and the Mata Allele Enhances Filamentation, Volume 2  
Author: MacKay, Trudy
Volume: Volume 2
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Mackay, T. (n.d.). Plos Genetics : Virulence Attributes and Hyphal Growth of C. Neoformans Are Quantitative Traits and the Mata Allele Enhances Filamentation, Volume 2. Retrieved from http://members.worldlibrary.net/


Description
Description : Cryptococcus neoformans is a fungal human pathogen with a bipolar mating system. It undergoes a dimorphic transition from a unicellular yeast to hyphal filamentous growth during mating and monokaryotic fruiting. The traditional sexual cycle that leads to the production of infectious basidiospores involves cells of both a and a mating type. Monokaryotic fruiting is a modified form of sexual reproduction that involves cells of the same mating type, most commonly a, which is the predominant mating type in both the environment and clinical isolates. However, some a isolates can also undergo monokaryotic fruiting. To determine whether mating type and other genetic loci contribute to the differences in fruiting observed between a and a cells, we applied quantitative trait loci (QTL) mapping to an inbred population of F2 progeny. We discovered that variation in hyphal length produced during fruiting is a quantitative trait resulting from the combined effects of multiple genetic loci, including the mating type (MAT) locus. Importantly, the a allele of the MAT locus enhanced hyphal growth compared with the a allele. Other virulence traits, including melanization and growth at 39 8C, also are quantitative traits that share a common QTL with hyphal growth. The Mac1 transcription factor, encoded in this common QTL, regulates copper homeostasis. MAC1 allelic differences contribute to phenotypic variation, and mac1D mutants exhibit defects in filamentation, melanin production, and high temperature growth. Further characterization of these QTL regions will reveal additional quantitative trait genes controlling biological processes central to fungal development and pathogenicity.

 

Click To View

Additional Books


  • Plos Genetics : Gc-biased Evolution Near... (by )
  • Plos Genetics : Statistical Estimation o... (by )
  • Plos Genetics : the Amidation Step of Di... (by )
  • Plos Genetics : Reduced Lentivirus Susce... (by )
  • Plos Genetics : the Evolution of Spinnab... (by )
  • Plos Genetics : a Functional Variant in ... (by )
  • Plos Genetics : Determinants of Cell- an... (by )
  • Plos Genetics : Mutations in a P-type At... (by )
  • Plos Genetics : Designing Sirna That Dis... (by )
  • Plos Genetics : an Essential Role of Var... (by )
  • Plos Genetics : Clines, Clusters, and th... (by )
  • Plos Genetics : a Combinatorial Amino Ac... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.