World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : P8, Volume 4

By Rulifson, Eric

Click here to view

Book Id: WPLBN0003926075
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : P8, Volume 4  
Author: Rulifson, Eric
Volume: Volume 4
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Publication Date:
Publisher: Plos


APA MLA Chicago

Rulifson, E. (n.d.). Plos Genetics : P8, Volume 4. Retrieved from

Description : Mutations in certain subunits of the DNA repair/transcription factor complex TFIIH are linked to the human syndromes xeroderma pigmentosum (XP), Cockayne’s syndrome (CS), and trichothiodystrophy (TTD). One of these subunits, p8/TTDA, interactswith p52 and XPD and is important inmaintaining TFIIH stability. Drosophila mutants in the p52 (Dmp52) subunit exhibit phenotypic defects similar to those observed in TTD patients with defects in p8/TTDA and XPD, including reduced levels of TFIIH. Here, we demonstrate that several Dmp52 phenotypes, including lethality, developmental defects, and sterility, can be suppressed by p8/TTDA overexpression. TFIIH levels were also recovered in rescued flies. In addition, p8/TTDA overexpression suppressed a lethal allele of the Drosophila XPB homolog. Furthermore, transgenic flies overexpressing p8/TTDA were more resistant to UV irradiation than were wild-type flies, apparently because of enhanced efficiency of cyclobutane-pyrimidine-dimers and 6–4 pyrimidine-pyrimidone photoproducts repair. This study is the first using an intact higher-animal model to show that one subunit mutant can trans-complement another subunit in a multi-subunit complex linked to human diseases.


Click To View

Additional Books

  • Plos Genetics : Origin and Functional Di... (by )
  • Plos Genetics : Histone Acetyl Transfera... (by )
  • Plos Genetics : Negative Regulation of t... (by )
  • Plos Genetics : Defining the Role of the... (by )
  • Plos Genetics : a Key Role for Chd1 in H... (by )
  • Plos Genetics : Phosphorylation of the C... (by )
  • Plos Genetics : Molecular Networks of Hu... (by )
  • Plos Genetics : Rsr-2, the Caenorhabditi... (by )
  • Plos Genetics : the Neural Crest Nc is a... Volume 4 (by )
  • Plos Genetics : Histone H3.3 Variant Dyn... (by )
  • Plos Genetics : Gene Conversion Occurs W... (by )
  • Plos Genetics : the Interplay of Reca-re... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.