World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : a Population Genetics-phylogenetics Approach to Inferring Natural Selection in Coding Sequences, Volume 7

By Nachman, Michael W.

Click here to view

Book Id: WPLBN0003931405
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : a Population Genetics-phylogenetics Approach to Inferring Natural Selection in Coding Sequences, Volume 7  
Author: Nachman, Michael W.
Volume: Volume 7
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Nachman, M. W. (n.d.). Plos Genetics : a Population Genetics-phylogenetics Approach to Inferring Natural Selection in Coding Sequences, Volume 7. Retrieved from http://members.worldlibrary.net/


Description
Description : Through an analysis of polymorphism within and divergence between species, we can hope to learn about the distribution of selective effects of mutations in the genome, changes in the fitness landscape that occur over time, and the location of sites involved in key adaptations that distinguish modern-day species. We introduce a novel method for the analysis of variation in selection pressures within and between species, spatially along the genome and temporally between lineages. We model codon evolution explicitly using a joint population genetics-phylogenetics approach that we developed for the construction of multiallelic models with mutation, selection, and drift. Our approach has the advantage of performing direct inference on coding sequences, inferring ancestral states probabilistically, utilizing allele frequency information, and generalizing to multiple species. We use a Bayesian sliding window model for intragenic variation in selection coefficients that efficiently combines information across sites and captures spatial clustering within the genome. To demonstrate the utility of the method, we infer selective pressures acting in Drosophila melanogaster and D. simulans from polymorphism and divergence data for 100 X-linked coding regions.

 

Click To View

Additional Books


  • Plos Genetics : Transposon Domestication... (by )
  • Plos Genetics : Fission Yeast Tel1Atm an... (by )
  • Plos Genetics : It’s All in the Timing ;... (by )
  • Plos Genetics : Expression Quantitative ... (by )
  • Plos Genetics : Rbm5 is a Male Germ Cell... (by )
  • Plos Genetics : Unveiling Novel Reco Dis... (by )
  • Plos Genetics : a High Density Snp Array... (by )
  • Plos Genetics : Histone Crosstalk Direct... (by )
  • Plos Genetics : Normal Dna Methylation D... (by )
  • Plos Genetics : Importance of Polg for D... (by )
  • Plos Genetics : E Unibus Plurum ; Genomi... (by )
  • Plos Genetics : Loss of Kindlin-1 Causes... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.